Buxton, one half of 6 Music's Adam & Joe, starts his new show, Adam Buxton's Big Mix Tape, on Easter Sunday. The 12midday-2pm show takes a weekly topic or theme and makes a "compilation tape" for listeners to share. His first guest will be the Mighty Boosh's Julian Barratt.
Cerys Matthews also starts her new two-hour show on Sunday mornings (10am-12 noon) on Easter Sunday.
Following Matthews andBuxton is Huey Morgan from 2pm to 4pm, then Jarvis Cocker's Sunday Service (4pm to 6pm) and Stuart Maconie's Freak Zone (6pm to 8pm).
6 Mix - which showcases DJ talent including Orbital, Erol Alkan and 2ManyDJs - moves to Sunday evenings (8pm to 10pm).
For the new Sunday line up in full, see below.
Radio Two and 6 Music controller Bob Shennan says the new schedule offers "a unique line-up of trusted guides to shine a light on hidden corners of the music world".
"With the addition of Cerys Matthews, Adam Buxton and the 6 Mix, 6 Music now promises to offer a distinctive day of eclectic music, presented by incredibly passionate and knowledgeable people, that I'm sure the listeners will enjoy," he adds.
New Sunday schedule in full:
7.00-10.00am: George Lamb
10.00-12.00pm: Cerys Matthews
12.00pm -2.00pm: Adam Buxton's Big Mix Tape
2.00-4.00pm: Huey Morgan
4.00-6.00pm: Jarvis Cocker's Sunday Service
6.00-8.00pm: Stuart Maconie's Freak Zone
8.00-10.00pm: 6 Mix
10.00pm-12.00midnight: Guy Garvey's Finest Hour
12.00midnight-1.00am: Don Letts' Culture Clash Radio