It is the star's fifth number one on the chart, following Destiny's Child releases Survivor, Bootylicious (both 2001), Lose My Breath (2004) and Crazy In Love - her 2003 collaboration with Jay-Z.
Best Thing I Never Had piled on 712 additional plays and nearly 13 million extra listeners last week to top the list with an audience of 71.58 million - the highest of any track for six weeks.
Eighteen plays on Radio 1 provided a top contribution of 18.18% to the track's listenership but its top supporters were five stations in the Capital FM network, each of which provided 62 or 63 plays.
The track also rockets 7-1 on the TV airplay chart, with its promotional videoclip logging 634 plays last week, 117 more than the previous week and 71 more than new runner-up, She Makes Me Wanna by JLS feat. Dev. Its biggest supporters: Chart Show TV (80 plays), MTV Hits (73) and MTV Base (61).
Still unable to make the Top 10 of the sales chart, Set Fire To The Rain retreats 1-2 on the radio airplay chart for Adele, with mixed fortunes. Its audience slides 7.81% to 62.79 million even as its plays increase 10.28% from 3,065 to 3,380.
More than 30 years after their initial breakthrough, Blondie still know how to attract radio's attention. The veteran group's new album Panic Of Girls spawns its second radio airplay chart hit in the form of What I Heard which soars 669-43 this week.
Like first single Mother, which reached number 31 last December, What I Heard is getting generous support from Radio 2, where it was aired 15 times last week - more than all but seven other songs.
Said support provided a massive 98.84% of the track's overall audience of 17.99 million. Eleven other stations aired the track a total of 35 times between them, with the top contribution of 11 plays coming from Original 106 FM in Aberdeen.
DJ Fresh's Louder (feat. Sian Evans) continues to dominate at Radio 1, where it was aired 25 times last week, three more than any other song. Despite that and the fact it has sold more than 277,000 copies in three weeks, the former number one hit has yet to breach the Top 10 of the radio airplay chart.
Climbing for the eighth week in a row however, it jumps 16-12, with 1,221 plays on 125 stations earning it an audience of 39.49 million. Radio 1's support provided 42.09% of its audience, however its biggest supporters in terms of plays, were eight stations from the Capital FM network, which aired it between 49 and 53 times apiece.