The DJ said on the breakfast show this morning: "We're off. I wanted to let you know. A couple more months of us, then it's someone else's turn. Thank you for listening."
Moyles took up the breakfast show role in 2004 and has won two gold Sony Radio Academy Awards since.
Although he is leaving, is contracted to Radio 1 until 2014 and is reported to be in talks about hosting a new show at the station. In May there were rumours that he was in negotiations to present a show on Radio 2.
In relation to standards set by the BBC Trust, Radio 1 is aiming to appeal to a younger audience and it is believed that 38-year-old Moyles is likely to be replaced by 26-year-old Greg James - who in April was moved to weekdays 4-7pm at the station replacing Scott Mills in the role.
Ben Cooper, controller BBC Radio 1 and BBC Radio 1Xtra, said: "I'd like to thank Chris. Quite simply he's been the most successful breakfast show host in Radio 1 history.
For the past eight and a half years he has been entertaining millions of listeners every morning, which is testament to his incredible talent as a broadcaster."
Moyles' replacement will be announced during Radio 1's new bulletin at 10.30am today (July 11).