The 18th EMAS, scheduled for Sunday November 6, will take place across three venues in the Northern Irish Capital: the Odyssey Arena (main stage) and two further locations that will be revealed soon.
MTV said it was the first time it had done this with the EMAS, although previous events - such as Madrid 2010 - have included one external stage alongside the main arena.
"We're really excited to celebrate Belfast and its rich musical heritage by showcasing MTV EMA performances from multiple sites throughout the city," said MTV EVP of talent and music programming Bruce Gillmer.
"These three stages will give fans a unique and unprecedented opportunity to experience the live music of the EMA."
Meanwhile, MTV announced today that Red Hot Chili Peppers will play the awards event.
Lady GaGa leads the nominations for the 2011 EMAs with six nods, followed by Katy Perry, Bruno Mars and Adele with four apiece and Coldplay with three.