The event, which is already sold out, takes place on Saturday November 22 at Glasgow's Old Fruitmarket, to raise funds for Nordoff-Robbins Music Therapy in Scotland
Orange Juice have not played together since 1982. Their singer Edwyn Collins suffered from a brain haemorrhage in 2005, although he has since made a recovery.
Donald MacLeod, chairman of the Nordoff-Robbins Music Therapy in Scotland Tartan Clef Fundraising Committee, and co-chair of the board of management says, "I am very excited about this year's Tartan Clef Music Awards which looks set to be the best yet with a stellar line-up and a great venue.
"The fact that it has come so far in such a short period of time is something myself and the fundraising board are very proud of. It is my view that it will very soon become just as important to the music industry as the Brits or the NME Awards.
"The funds and recognition it raises for Nordoff-Robbins Music Therapy in Scotland is invaluable and helps guarantee music therapy for all those who benefit from it."
Collins says he has fond memories of the band and is looking forward to seeing them again.
This year's event will also see Scotland's largest music venue, the Glasgow SECC, on board as a headline sponsor as well as competing for a people's choice award for best live act.