The Sheffield band's status as free agents has unsurprisingly attracted a host of industry interest. Labels understood to have made enquiries into signing them include Sony's Columbia, which currently has the likes of Kasabian, Miles Kane and The Vaccines on its books.
However Domino, which has released all four Monkeys albums since record-breaking debut Whatever People Say I Am, That's What I'm Not, is the clear front-runner, and so far the only label to have even discussed the next album with the band.
"It is true that the latest album from Arctic Monkeys is their last under the current arrangement with Domino," manager Ian McAndrew told Music Week.
"We have not entered into discussions with any other prospective label although we have received plenty of enquires. Domino has been a great label for the band and afforded us fantastic support and therefore will be at the front of any future discussions we may have about further albums."
The Monkeys' loyalty to Domino boss Laurence Bell was apparent in a tribute video they made in response to the exec picking up his Pioneer gong at the AIM Awards earlier this month.
Songwriter and lead singer Alex Turner said of Bell: "He's turned me on to some bloody great records," whilst praising the exec's "great guidance" - which included "knowing his way around a barbecue".
The Sheffield band's last LP, Suck It And See - released by Domino in June - reached No.1 in the Official UK Album Chart.
It will be the first Arctic Monkeys album to spawn four singles, with Black Treacle lined up for a 2012 release.