The plaque will be erected at the Hare & Hounds in Birmingham's Kings Heath where the reggae outfit first performed on February 9 1979.
The band's members Robin Campbell (guitars/vocals), Brian Travers (sax), James Brown (drums), Earl Falconer (bass), Norman Hassan (percussion) and Astro (trumpet) will pop along to see the plaque unveiled on October 4 at 11.30am.
PRS for Music Chairman Guy Fletcher OBE said: "UB40 has made an incredible contribution to the music scene in a career spanning three decades and they are still going strong. The much-loved band has placed more than 50 singles in the UK Singles Chart, achieved considerable international success and sold over 70 million records - a superb achievement."
Robin Campbell, who set the band up with his brother Ali, said: "I'm humbled that the birthplace of UB40 has been chosen to be marked in this way. It's a pleasure to return to the place where we first performed."
The owner of the pub was also delighted the Hare & Hounds will now be part of Birmingham's rich musical history. Adam Reagan said: "We are delighted that such an important moment of UB40's history will be recorded at Hare & Hounds, a venue that is now a base for some of the area's best up and coming artists."