The event, which returns to Worthy Farm from June 26-30 following a fallow year, has unveiled its first line-up poster for 2019.
Saturday headline act The Killers previously headlined the Pyramid Stage in 2007 and played a surprise set on the John Peel Stage in 2017. Sunday headliners The Cure, meanwhile, will perform at the festival for the first time since 1995, equalling Coldplay's record as four-time headliners.
Other acts newly announced include Janet Jackson, George Ezra, Liam Gallagher, Miley Cyrus, Tame Impala, The Chemical Brothers, Vampire Weekend, Lauryn Hill, Christine And The Queens, Two Door Cinema Club, Jorja Smith, Bastille, Billie Eilish, Hozier, Sigrid, Snow Patrol, Cat Power, Wu-Tang Clan, Anne-Marie, Years & Years, Sheryl Crow, The Good, The Bad & The Queen, Hot Chip, Stefflon Don, Jon Hopkins, Santigold and The Streets. Janelle Monae and Kylie Minogue had already been confirmed, with Kylie set for the Sunday afternoon 'legends' slot.
Although all three Pyramid Stage headliners are male, 42% of the currently announced line-up is female.