The event is expected to draw 70,000 fans to Camperdown Park in Dundee, when it returns to the Scottish city from Friday, May 22-Sunday, May 24.
Big Weekend is now in its 17th year, in 2019, The 1975, Little Mix and Miley Cyrus all took to the stage in Middlesbrough.
The show took place in Dundee for the first time in 2006, when Pink, Snow Patrol, Sugababes and The Streets were among the artists on the bill.
Calvin Harris, Biffy Clyro and AJ Tracey have also been added to the line-up as part of this first wave of confirmations.
Meanwhile, Dua Lipa promised new music from her upcoming second album, Future Nostalgia.
More names will be added to the line-up over the coming weeks.